Genes matter!

Genes 101: Are Human Genes Patentable Subject Matter?

Hypertrophic cardiomyopathy--a matter of genes.

CAN J ANESTH 55: 5 www.cja-jca.org May, 2008 outcome of the infraclavicular brachial plexus blocks. At our institution, instead of making use of “three factors,” we utilize one common endpoint to ensure the success of the blocks. It is the deposition of the local anesthetic (LA) around the brachial plexus cords. We believe that having the LA “bathe” the nerves is important in predicting the suc...

Hox Genes: It’s All a Matter of Context Dispatch

Hox genes play a major role in the morphological diversification of the anteroposterior body axis of animal embryos by switching the fates of segments between alternative developmental pathways [1]. In their role of controlling segment diversity, Hox proteins are responsible for many different morphological structures and cell types within a given segment. But it is still largely a mystery how ...

microRNA regulation of Hox genes: RNA tails matter

Efficient production of haematopoietic stem (HPS) cells from embryonic stem (ES) cells or from induced pluripotent stem (iPS) cells requires a thorough understanding of haematopoietic differentiation pathways. On p. 2829, Gordon Keller and colleagues show that generation of HPS cells from ES and iPS cells follows the same steps as haematopoietic development in the embryo. They induced ES cells ...

Hox Genes: It's All a Matter of Context

Recent studies provide compelling new evidence that Hox gene effects depend on fine-structure spatial and temporal information. Further, in a specific cell type, only one or a few downstream genes may mediate Hox morphogenetic functions. If this is generally true, it will have important implications for how Hox regulatory networks operate and evolve.